Out-of-hospital administration of IV glucose-insulin-potassium in patients with suspected ACS: the IMMEDIATE trial
Jun 18, 2012
Overview:The authors investigated whether the immediate intravenous (IV) administration of glucose, insulin and potassium (GIK) in the setting of emergency medical services would reduce ischemia-related arrhythmias and myocardial injury in suspected acute coronary syndromes. Compared with placebo, GIK administration was... more
A Pilot Project of Familial Screening in Patients with Bicuspid Aortic Valve Disease
Jul 15, 2013
Overview:Background BAV is a risk factor for aortic valve disease in adults. It may be the most common cardiovascular malformation, with an estimated incidence of 0.6% to 1.36%. Previous studies attempted to investigate the hypothesis that clinically asymptomatic BAV may... more
Hypertension and Stroke: Update on Treatment
Apr 30, 2021
Overview:Stroke is the second most common cause of mortality worldwide and the third most common cause of disability.1 Although there has been a global trend towards a reduction in stroke incidence, prevalence and mortality since the 1990s, the overall stroke burden... more
Sodium–Glucose Cotransporter 2 Inhibitors In Heart Failure
Nov 01, 2020
Overview:Potential Mechanisms Of Action, Adverse Effects And Future Developments Type 2 diabetes (T2D) remains a major cardiovascular (CV) risk factor1–5 and it confers an approximately two- to threefold fold excess risk for coronary heart disease, including MI, stroke and heart... more
Antiplatelet Therapy In Acute Coronary Syndrome
Oct 10, 2018
Overview: Acute coronary syndrome (ACS) is a term used to encompass unstable angina (UA) and myocardial infarction (MI) with or without electrocardiographic (ECG) evidence of ST-segment elevation. Antiplatelet therapy has formed the backbone of ACS management for decades and the... more
Resistant Hypertension: A Real Entity Requiring Special Treatment?
Aug 01, 2016
Overview:The concept of resistant hypertension (RH) has received great attention in the past years, mainly as a possible target population for innovative therapeutic strategies. An increasing number of original articles and commentaries have focused on the clinical significance, prognosis and... more
Cardiovascular Management of Adults with Marfan Syndrome
May 09, 2018
Overview: Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant... more
Key Recent Advances In Atherosclerosis Treatment With Modern Lipid-Lowering Drugs: The New Frontier With PCSK9 Inhibitors
Jan 04, 2019
Overview:Hypercholesterolemia has been known for several years to be a major risk factor in the development of atherosclerosis and consecutively cardiovascular disease. This epidemiological concept has been widely confirmed using different strategies that have reduced low-density lipoprotein (LDL) levels and... more
Losartan versus candesartan in HF
Jun 18, 2012
Overview:Association of treatment with losartan vs candesartan and mortality among patients with heart failure In the present study the authors asked whether losartan use is associated with increased all-cause mortality in heart failure (HF) patients compared with candesartan. Among patients... more
Left Ventricular Remodelling: A Problem In Search Of Solutions
Mar 01, 2018
Overview: The term cardiac remodelling (REM) is used to define changes that produce geometrical rearrangement of the normal structures of the heart, together with complex biological and molecular alterations. REM affects the heart at the level of the cardiomyocyte, the... more