Trimetazidine and Other Metabolic Modifiers
Jul 22, 2020
Overview:Although cardiovascular mortality has declined progressively in developed countries, ischaemic heart disease (IHD) and chronic stable angina cause a worse prognosis and poor quality of life and can dramatically increase healthcare costs.1–4 Traditionally, chronic stable angina has been interpreted as reversible... more
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomization study
Jun 18, 2012
Overview:The present study sought to assess whether there is a causal relationship between raising HDL and the risk for myocardial infarction (MI). Using a mendelian randomization, the authors found that in patients with genetically higher HDL the risk of MI... more
Dilatation of the Remaining Aorta After Aortic Valve or Aortic Root Replacement in Patients With Bicuspid Aortic Valve: A 5-Year Follow-Up
Aug 16, 2013
Overview:Background Bicuspid aortic valve (BAV) is the underlying pathology in as many as 1/3 of patients who undergo aortic valve replacement (AVR). It is now widely accepted that an inherent aortopathy exists independent of functional valvular pathology in many patients... more
Typical angina without significant coronary stenosis: comparison of clinical profile, circadian presentation, and long-term follow-up between patients with and patients without vasospastic angina
Aug 07, 2013
Overview:Background The spectrum of patients with chest and no significant coronary stenosis is broad, with a wide range of lumen obstruction (from smooth completely normal coronary arteries to those with lesions <50%) and also including abnormal vasomotion (vasospastic angina-VA, microvascular... more
HRT after MI: adverse events
May 02, 2012
Overview:Discontinuation of hormone replacement therapy after myocardial infarction and short term risk of adverse cardiovascular events: nationwide cohort study Background Guidelines recommend discontinuation of hormone-replacement therapy (HRT) in women diagnosed with coronary artery disease. Discontinuation of HRT can be troublesome... more
Testosterone and the Heart
Mar 09, 2021
Overview:Testosterone deficiency (TD) is a well-established and significant medical condition.1,2 It has been defined as a clinical and biochemical syndrome, associated with older age and comorbidities.3 It is characterised by a deficiency in serum androgen levels, with or without reduced genomic sensitivity... more
Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation MI patients with expected delays due to long-distance transfers
Jun 18, 2012
Overview:This investigates the safety and efficacy of a pharmaco-invasive reperfusion strategy utilizing half-dose fibrinolysis combined with transfer for immediate PCI in STEMI patients presenting to remote rural hospitals. The authors found no significant differences in 30-day mortality, stroke, major bleeding,... more
Retraction of the Jikei Heart Study
Oct 21, 2013
Overview:In 2007, the Lancet published the results of the Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study (1). According to the authors, the addition of the angiotensin... more
High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study
Jun 18, 2012
Overview:The authors of this study investigated whether there is a difference between younger and older patients in the ability of thienopyridine antiplatelet drugs to inhibit platelet responsiveness. They found that, in a population of patients chronically treated with aspirin plus... more
Do bisphosphonates slow the progression of aortic stenosis?
May 02, 2012
Overview:Background Aortic stenosis (AS) in the elderly is commonly associated with leaflet calcification and thickening leading to progressive obstruction of the aortic valve. Calcification has been shown to have a central role in the progression of AS along with inflammation.... more