Chest pain in aortic stenosis: novel diagnostic and therapeutic data
Jul 25, 2017
Overview:By Dennis Cokkinos Angina pectoris (AP) in aortic stenosis (AS) is not unusual. It can be seen in up to 75% of patients. It is associated with coronary artery disease (CAD) in 50-74% of patients; it’s for diagnosing CAD sensitivity... more
Coronary Artery Spasm And Perivascular Adipose Tissue Inflammation: Insights From Translational Imaging Research
Aug 24, 2020
Overview:Coronary Artery Spasm and Adventitial Inflammation Coronary artery spasm plays an important role in the pathogenesis of a wide range of ischaemic heart disease, not only in variant angina, but also in other forms of angina pectoris and myocardial infarction.1,2 Recent... more
The Role Of Inflammation In Diabetes: Current Concepts And Future Perspectives
Feb 08, 2021
Overview:Diabetes is a multifaceted metabolic disorder affecting the glucose status of the human body. Impaired glucose tolerance and hyperglycaemia are the main clinical and diagnostic features and the result of an absolute or relative insulin deficiency or resistance to its... more
Predictors of Ascending Aortic Dilation in Bicuspid Aortic Valve Disease: A Five-year Prospective Study
Jun 03, 2015
Overview:The article focuses on the progression of aortic dilation in bicuspid aortic valve (BAV) individuals. The authors prospectively evaluate an asymptomatic cohort of BAV individuals and assess the rate of aortic growth with time. They find a mean annual rate... more
Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Prevention of Spontaneous Myocardial Infarction in Subjects With Stable Ischemic Heart Disease
Jul 09, 2013
Overview:Background CAD is the leading cause of death worldwide, contributing to over 7.2 million deaths annually. Early revascularization has been well validated to show a reduction in cardiovascular events in the management of ST segment elevation MI1-3. In addition, revascularisation... more
Influence of mitral regurgitation repair on survival in the Surgical Treatment for Ischemic Heart Failure (STICH) Trial
Jun 18, 2012
Overview:This study assessed the survival impact of functional mitral regurgitation (MR) in patients with ischemic heart disease and low ejection fraction (EF<35%). The authors also assessed the impact of adding mitral valve repair (MVrep) at the time of CABG on... more
Mapping Technologies for Catheter Ablation of AF Beyond Pulmonary Vein Isolation
Jan 17, 2022
Overview: Despite substantial advancements in rhythm control strategies during the last decade, AF remains a daily clinical problem with a steadily growing socio-economic burden worldwide.1 In the last few years, long-term success rates of ablation procedures have stood between 60% and... more
Predictions in Cardiovascular Disease in 2040
May 12, 2021
Overview:Foreword - Dennis V. Cokkinos, Professor Emeritus (cardiology), University of Athens Arterial Hypertension - Giuseppe Mancia, Emeritus Professor of Medicine, University Mifano-Bicocca Heart Failure - What Lies Ahead - Dimitris A. Sideris, Professor Emeritus (Cardiology) University of loannina The Future of the... more
A randomized, controlled trial of simvastatin versus rosuvastatin in patients with acute myocardial infarction: the Secondary Prevention of Acute Coronary Events–Reduction of Cholesterol to Key European Targets Trial.
Aug 17, 2015
Overview:The debate over the cholesterol hypothesis and statins has raged for decades. The early period following the onset of acute coronary syndrome represents a critical stage of coronary heart disease, with a high risk of recurrent events and deaths. The... more
Qsymia Offers ‘Really Effective’ Weight Loss
Apr 28, 2017
Overview:By Professor Juan Tamargo, Madrid, Spain Qsymia is a formulation of two off-patent drugs already on the market: immediate-release phentermine and controlled-release topiramate. Phentermine is an amphetamine-like compound, currently licensed as a short-term weight loss agent due to its central... more